Cabo Montes de Oca, Juan Luis

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Main Reports, Publications and Patents

  1. Clinical and epizootiological report of the equine infectious anemia in Cuba. First Journey of Veterinary Science, March 1978.
  2. Clinical and epizootiological report of the icterohemoglobinuria bacilar of cattle in Cuba. First Journey of Veterinary Science, March 1978.
  3. Recovering of meat products for an annual amount of 36,000 pounds, through a modification of the technology, First Journey of Veterinary Science, March 1978.
  4. Serologic diagnosis of cattle fasciolosis, using feces antigen and countercurrent immuno diffusion, Veterinary World Congress. Moscow, 1979.
  5. Clinic and epizootiologic report of canine parvovirosis in Cuba, Cuban Review of Veterinary Science, 1980.
  6. Clinic report of feline viral peritonitis in Cuba, Second Journey of Veterinary Science, Cuba 1981.
  7. Plasmic catalase in the canine mammary neoplasm diagnostic. Cuban Journey of Veterinary Science, 1981.
  8. Innovative gasometrical technique to measure plasmic catalase, Second Journey of Veterinary Science, 1981.
  9. Product with immuno correcting activity and procedure to obtain it. Author’s Invention Certificate 11 no. 22233. ONIITEM, March 4. 1994.

Scientific Field of Interest and Research Experience

Fields of Interest

Immunological Research

List of publications

  1. Cabo, Montes de Oca, J.L.. and Montesinos G.R., Reticoid immunopotentiator. Effect in the treatment of chronic eczema and psoriasis. Thesis presented to the National Scientific Council, Ministry of Health, Havana, 1988.
  2. Cabo, Montes de Oca, J.L. and Montesinos G.R. Therapy and medication called Dermune, for making dermatitis less sensible, specially psoriasis and chronic eczema. Author’s Invention Certificate, Request registered to no 194.88 at ONIITEM 12,1,88.
  3. Cabo, Montes de 0ca, J.L. and Montesinos G.R., Product and procedure for obtaining immunological mediators universe for immunodeficiences. Author’s Invention Certificate. Request registered as no. 31.90 at 0NIITEM 12,9,90.
  4. Cabo, J.L. and Montesinos Rodriguez G.R. New treatment based on the obtainment of immunological mediators through the autohemotherapeutical system. Excerpt of the 12th Pan American Congress of Veterinary Science, July 31-August 4, 1990, page 88, Havana. Cuba.
  5. Cabo, J.L. and Montesinos Rodriguez G.R. New therapeutic modality based on the obtainment of immunological mediators through the autohemotherapeutical activation of the reticule-endothelial system. Summary of the World Veterinary Congress, August l8-23,1991. Río de Janeiro, Brazil.
  6. Cabo, Montes de Oca, J.L., Hernández Torres, Guillermo and Pérez Sotolongo, E, Results on the effectiveness of the treatment of 80 patients of dermatitis of the Specialized Hospital Guillermo Fernandez Hernandez Baquero, with the Dermune C.H.. Labiofam Scientific Journey,1993, Havana. Cuba.
  7. Cabo, Montes de Oca, J.L., Hernández Torres, G. and Pérez Sotolongo, E. Toxicological study of active principle of the crème Dermune C.H., Labiofam Scientific Journey, 1994. Havana.Cuba.
  8. 8-Cabo, Montes de Oca, J.L., y Montesinos Rodriguez, G.R., Product with immuno correcting activity and procedure to obtain it. Author’s Invention Certificate 11 no. 22233, 0NIITEM, March 4,1994.
  9. Cabo, Montes de Oca, J.L. Torres, G.H. y Martha Paradoa Perez. Dermune C.H. Hypothesis of action on immunity diseases. Labiofam Scientific Journey, 1995, Havana, Cuba.
  10. Elia, M. Pérez Sotolongo, Elena Rodríguez, Hernández, G.H. y Cabo, J.L., Dermune C.H. crème in the dermatitis and psoriasis treatment. Labiofam Scientific Journey, 1995, Havana.Cuba.
  11. Cabo, Montes de Oca, J.L. New treatment of dermatitis, X National Congress of Pharmacological Science, August 3l-00, Panama. City, Panama.

Project Dermune CH

Dermune C.H. is an hemoderivated product obtained from dogs for to be employed in immunologically mediated diseases as psoriasis, allergic dermatitis and plane liquen. Within pre-clinical studies it has been employed in parenteral form. The experiences have been conducted during ten years of applications of the cream in patients with psoriasis, allergic dermatitis and plane liquen in the specialized dermatological hospital ¨Guillermo Fernandez Hernandez Baquero¨ of the Cuban Ministry of Health.

The product is obtained through the inflammatory stimulus of the subcutaneous tissue of dogs. Pharmacological studies also have been performed, on toxicity upon a unique doses, acute toxicity upon repeated doses, sub-chronic toxicity and primary irritation in skin and mucous.

Anti-tumor studies have been conducted in the l1210 tumor of the mice and in the transmisible venereal tumor with good results.

The Cuban Center of Research and Development of Medical Products, extended a recommendation letter for the development of DERMUNE C.H. which was submitted to the Director of Science and Technology of the Cuban Ministry of Health.

The more fruitful work has been the treatment with cream to patients of the mentioned hospital, during ten years, since the low cost and the easiness of the obtention of the basic components of the product. In spite of these results the process for the medical registering has been very slow. The product to be employed in animals has been also delayed because, due to the lack of resources, the one used in humans has received priority.

Is our main interest with this project, to propose cooperative development and characterization of this product directed, in a first stage, to veterinary applications in immunomediated diseases.

Main Objectives

  1. Obtention of the total product on skin dogs and standarization of the process for the subsequent obtention of the injectable immunological preparates.
  2. To perform clinical trials for the confirmation of the healing action of the products.

Plan of Activities

Objective 1

  1. Obtention of the total product from the subcutaneous tissue of experimental dogs.
  2. Ultracentrifugation of total the product.
  3. Elimination of the deposit.
  4. Bacteriological filtration of the residual product.
  5. Ultrafiltration of the resulting substance by membranes of the following types: 50,000, 30,000, 20,000, 10,000,...etc. NMWC.
  6. Fillement, preservation, refrigeration and liophilization of the product.
  7. Proteins and polipeptides characterization.
  8. Standarization of the process.

Task 2

Applications of the preparates in dogs affected by atopic dermatitis, chronic eczema, contact dermatitis,etc.. The diagnostic criteria for the diseases, before and after treatment, will be based on the clinic and laboratory diagnosis performed by specialized technicians.

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